Curriculum Vitae

headshot-1-Kevin

Education

Brigham Young University
BS, 1981-1985, Mechanical Engineering

Brigham Young University
MS, 1985-1986, Mechanical Engineering

University of Texas Southwestern
Ph.D., 1989-1995, Biomedical Engineering
Medical Center at Dallas

Appointments

1986-1988 | Software Engineer
General Dynamics, San Diego, CA

1988-1989 | Structural Dynamics Engineer
General Dynamics, San Diego, CA

1989-1995 | Graduate Research Assistant
University of Texas Southwestern Medical Center at Dallas

1993-1994 | Student Intern
Quest Medical Inc., Allen, TX

1995-1996 | Assistant Instructor
Biomedical Engineering, University of Texas at Arlington

1996-1997 | Visiting Assistant Professor
Biomedical Engineering, University of Texas at Arlington

1997-2003 | Assistant Professor
Biomedical Engineering, University of Texas at Arlington

2003-2005 | Associate Professor
Biomedical Engineering, University of Texas at Arlington

1997-present | Special Adjunct Professor
University of Texas Southwestern Medical Center at Dallas

2000-2005 | President, Founder and Chief Scientific Officer
TissueGen Inc.

2005-present | Founder and Chief Scientific Officer
TissueGen, Inc.

2005-present | Adjunct Professor
Bioengineering, University of Texas at Arlington

Honors

1978-1979 | Dean’s Honor Role
Wright State University, Dayton, Ohio

1981-1982 | Dean’s Honor Role
Brigham Young University

1981-1985 | Academic Scholarship
Brigham Young University

1991-1992 | President of Biomedical Engineering Student Society
University of Texas Southwestern medical Center at Dallas

1995 | Alfred and Jan Potvin outstanding Ph.D. student of the year
University of Texas at Arlington

1997 | Young Investigator Award
35th Japanese Society for Artificial Organs

2002 | College of Engineering
“Outstanding Educator of the Year”

Membership in Professional Societies

Controlled Release Society

Ad-Hoc Reviewer for the Following Journals

Tissue Engineering

Advanced Functional Materials

Journal of Biomaterials Science, Polymer Edition

Tissue Engineering

Curriculum Vitae

Kevin D. Nelson, Founder and Chief Scientific Officer

Peer Reviewed Journal Publications
  1. Eberhart RC, Huo HH and Nelson KD: Cardiovascular materials. MRS Bull 16(9):50-54, 1991. (Review Article)
  2. Walker AK, Wu Y, Timmons RB, Kinsel GR, Nelson KD: Effects of Protein Surface Interactions on Protein Ion Signals in MALDI Mass Spectrometry. Analytical Chemistry 71(1):268-272 (1999)
  3. Carlisle ES, Mariappan MR, Nelson KD, Thomes BE, Timmons RB, Constantinescu A, Eberhart RC, Bankey PE.: Enhancing hepatocyte adhesion by pulsed plasma deposition and polyethylene glycol coupling. Tissue Engineering 6(1):45-52, 2000
  4. Walker AK, Land CM, Kinsel GR, Nelson KD: Quantitative Determination of the Peptide Retention of Polymeric Substrates Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry 11(1): 62-68, 2000
  5. Alikacem N., Yoshizawa T., Nelson KD, and Wilson CA. Quantitative MR Imaging Study of Intravitreal Sustained Release of VEGF in Rabbits. Invest. Ophthalmol. Vis. Sci., 41(6):1561-1569, May 2000
  6. Rangappa N, Romero A, Nelson KD, Eberhart RC, Smith GM: Laminin-coated poly(L-lactide) filaments induce robust neurite growth while providing directional orientation. J Biomed Mater Res. 2000 Sep 15;51(4):625-34.
  7. Hu Z, Wang C, Nelson KD, Eberhart RC.: Controlled Release from a Composite Silicone/Hydrogel Membrane. ASAIO Journal 46(4):431-434,2000
  8. Teri T Ngo, Paula J Waggoner, Andres A. Romero, Kevin D. Nelson, Robert C. Eberhart, and George M. Smith ‘Poly(L-Lactide) microfilaments enhance peripheral nerve regeneration across extended nerve lesions. J Neurosci Res. 2003 Apr 15;72(2):227-38.
  9. Shih-Horng Su, Robert Y.N. Chao, Charles Landau, Kevin D. Nelson, Richard B. Timmons, Robert S. Meidell, Robert C. Eberhart. Expandable Bioresorbable Endovascular Stent: I. Fabrication and Properties. Annals of Biomedical Engineering 31:(6):667-77, 2003 Jun
  10. Robert C. Eberhart, Shih-Horng Su, Kytai Truong Nguyen, Meital Zilberman, Liping Tang, Kevin D. Nelson and Peter Frenkel. Bioresorbable Polymeric stents: Current Status and Future Promise. J Biomaterials Science: Polymer Edition 14 (4): 299-312 (2003) Review Article
  11. Sagiv A, Parker N, Parkhi V, Nelson KD. Initial burst measures of release kinetics from fiber matrices. Ann Biomed Eng. 2003 Oct;31(9):1132-40
  12. Kevin D. Nelson, Andres Romero, Paula Waggoner, Brent Crow, Angela Borneman, George M. Smith. Technique Paper for Wet-Spinning Poly(L-lactic acid) and Poly(DL-lactide-co-glycolide) monofilament fibers. Tissue Engineering 9(6):1323-30 (2003)
  13. Elizabeth M. Cronin, Frederick A. Thurmond, Rhonda Bassel-Duby, R. Sanders Williams, Woodring E. Wright, Kevin D. Nelson, Harold R. Garner. ‘Protein-coated poly(L-lactic acid) fibers provide a substrate for differentiation of human skeletal muscle cells’. Journal of Biomedical Materials Research Part A, 69(3): 373-381 (2004)
  14. Tang, Xiao-Qing; Cai, Jie; Nelson, Kevin D; Peng, Xue-Jun; Smith, George M. Functional repair after dorsal root rhizotomy using nerve conduits and neurotrophic molecules. European Journal of Neuroscience. 20(5):1211-1218, September 2004.
  15. Cai J, Peng X, Nelson KD, Eberhart R, Smith GM. Synergistic improvements in cell and axonal migration across sciatic nerve lesion gaps using bioresorbable filaments and heregulin-beta1. J Biomed Mater Res A. 2004 May 1;69(2):247-58
  16. Crow BB, Borneman AF, Hawkins DL, Smith GM, Nelson KD. ‘Evaluation of in vitro drug release, pH change, and molecular weight degradation of Poly(L-lactic acid) and Poly(D,L-lactide-co-glycolide) fibers’. Tissue Engineering 11 (7-8), Jul-Aug. 2005, pp.1077-1084
  17. Meital Zilberman, Kevin D. Nelson and Robert C. Eberhart. Mechanical Properties and In Vitro Degradation of Bioresorbable Fibers and Expandable Fiber-Based Stents. Journal of Biomedical Materials Research Part B: Applied Biomaterials. Vol. 74B (2), August 2005: 792-799
  18. Jie Cai, Xuejun Peng, Kevin D. Nelson, Robert Eberhart, George M. Smith. Permeable guidance channels containing microfilament scaffolds enhance axon growth and maturation. J Biomed Mater Res A. 75A(2):374-386 (2005)
  19. Crow BB, Nelson KD. ‘Release of bovine serum albumin from a hydrogel-cored biodegradable polymer fiber’ Biopolymers 81(6):419-27(2006)
  20. A. Braden, M. Roner, J. Ganter , and K. Nelson. Enhanced Delivery of Bioactive Molecules to Intracellular Environments Utilizinga Cytosolically Reducable Grafted Analogof Polyethylenimine. Journal of Nanoscience and Nanotechnology 7, 1-12, 2007
  21. A. Braden, M. Roner, J. Ganter, and K. Nelson. Transport of Biologically Active Molecules to Intracellular Environments Utilizing a Lyzosomally Cleavable Random Block Copolymer of Polyethylenimine. Journal of Biomedical Nanotechnology 3, 1-11, 2007
Book Chapters

Eberhart, R.C., Su, S-H., Nguyen, K.T., Zilberman, M., Tang, L. Nelson, K.D., and Frenkel, P. Bioresorbable polymeric stents: current status and future promise. In Cells, Proteins and Materials. H. Sheardown and S.L. Cooper, (Eds.). VSP, Utrecht, 2003, pp. 389-402.

Full Papers Without Complete Review
  1. Nelson, K.D., Adams B.L., Fricke W.G.Jr.: Correlation on Earing in Hot Rolled 3004 Aluminum with the Crystallite Orientation Distribution Function. Eigth International Conference on Textures of Materials, ICOTOM8. Ed. Kallend JS, and Gottstein G. Metallurgical Society 1988, pages 1097-1102
  2. Nelson KD, Huo HH, Kulik EA, Sevastianov VI, Constantinescu A. and Eberhart RC: Analysis of albumin deposits on hydroxylated siloxane films: Implications for surface treatment of medical devices. ASAIO J., 39(3):M310-M313, 1993
  3. Nelson KD, Elsenbaumer R, Pomerantz M, Eberhart RC: High Affinity Poly(Ethylene Oxide) for Improved Biocompatibility. ASAIO J., 42(5): M884-M889, 1996
  4. Ye Y-W., Landau C., Meidell RS., Willard J., Moskowitz A., Aziz S., Carlisle E., Nelson KD., Eberhart RC.,: Improved Microporous Bioresorbable Intravascular Stents for Gene therapy Applications, ASAIO J, 42(5): M823-M827, 1996
  5. Rajasubramanian S, Nelson KD, Shastri P, Consantinescu A, Kulkarni P, Jessen M, Eberhart RC: Design of an oxygenator with enhanced gas transfer efficiency. ASAIO J, 43(5): M710-M714, 1997.
Invited Presentations

Nelson, KD., Prager M., Pomerantz M, Elsenbaumer R., Eberhart RC., Albumin Passivation by Warfarin Attached to Poly(Ethylene Oxide)., By invitation of Dr. Kazunori Kataoka at the Science University of Tokyo, September 16, 1997

Kevin D. Nelson, Brent B. Crow, Deepal Panchal, Joana Ganter, Jason Fleming. Drug delivery fibers for potential solid tumor treatment, IEEE MetroCon, Arlington, TX, September 29, 2004

Presentations and Abstracts
  1. Nelson, K.D., Tsai, C.C., Huo, H.H. and Eberhart, R.C.: An improved method to enhance the biocompatibility of silicone rubber; Hydroxylation by hydroboration. Proc 9th South Biomed Eng Conf, Pergamon Press, 1990. (Abstract)
  2. Huo, H.H., Tsai, C.C., Nelson, K.D., and Eberhart, R.C.: PEO-modified vinylmethyl-siloxane as a biomaterial coating. Proc 9th South Biomed Eng Conf, Pergamon Press, 1990. (Abstract)
  3. Tsai, C.C., Nelson, K.D., and Eberhart, R.C.: Method to reduce complement activation by silicone rubber. Extracorp. Life Support Organization, Ann Arbor, November 1990. (Abstract)
  4. Nelson, K.D., Tsai, C.C., Kulik, E.A., Sevastianov, V.I., and Eberhart, R.C.: Analysis of hydroxylated siloxane films for medical devices. Houston Society for Engineering in Medicine and Biology, Houston, TX, Feburary, 1993. (Abstract)
  5. Nelson, K.D., Tsai, C.C., Kulik, E.A., Sevastianov, V.I., and Eberhart, R.C.: Analysis of albumin deposits on hydroxylated siloxane films: Implications for surface treatment of medical devices. 39th Annual Meeting ASAIO, New Orleans, LA, April 29 – May 1, 1993. (Abstract)
  6. Eberhart RC., Nelson KD., Ye Y-W., Landau C., Willard JE., Meidell RS.: Biomaterials and Gene Therapy: Prospectives and Problems. Society for Biomaterials Annual Meeting, New Orleans, LA. April 30-May 4, 1997 (Abstract)
  7. Nelson KD., Su S., Phansalkar AR., Romero AA., Ye Y-W., Eberhart RC., Landau C., Meidell RS.: New Fabrication Techniques for Polymeric Intravascular Stents. IMECE97, Dallas, TX. November 16-21, 1997
  8. Nelson KD., Phansalkar AR., Romero AA., Eberhart RC., Landau C., Meidell RS.: Degradation of Poly(L-lactic acid) Monofilaments. IMECE97, Dallas, TX. November 16-21, 1997
  9. Eberhart RC., Nelson KD., Ye Y-W., Landau C., Willard JE., Meidell RS.: Local Delivery of Gene Therapy via Porous Stents. Invited paper – Mini-symposium on Restenosis and Drug Delivery Strategies. Controlled Release Society, June 1997, Stockholm Sweden.
  10. Nelson KD, Romero AA, Su S, Phansalkar AR, Ye, Y-W, Eberhart RC, Landau C, Meidell RS.: Recent Advances in Porous, bioresorbable Intravascular Stents for Gene Therapy. 35th Japanese Society for Artificial Organs, September 14-15, 1997, Yokohama Japan.
  11. Su SH, Nelson KD, Romero AA, Meidell RS, Landau C, Eberhart RC. New Fabrication Procedure for Polymeric Stents with Smooth Interior and Porous Exterior Surfaces. Society for Biomaterials Conference, April 22-26, 1998, San Diego, CA.
  12. Nelson KD, Phansalkar AA, Landau C, Meidell RS, Eberhart RC.: Tissue Engineering via Bioresorbable Microporous Stents that Deliver Recombinant Adenovirus Gene Transfer Vectors to the Arterial Wall. BECON symposium at the NIH, February 27-28, 1998
  13. Eberhart RC, Su S., Li J., Nelson, KD.: Influence of blood flow rate on platelet adhesion to medical devices as measured by gamma scintigraphy. Biomedical Engineering Society Annual Meeting, Cleveland, OH. October 10-13, 1998.
  14. Nagarathnamma R, Nelson KD, Romero AA, Smith G: In vitro growth of axons on laminin coated fibers. Biomedical Engineering Society Annual Meeting, Cleveland, OH. October 10-13, 1998.
  15. Romero AA, Smith GM, Nelson KD.: Biodegradable Fibers By A Wet-Spinning Process. Biomedical Engineering Society Annual Meeting, Cleveland, OH. October 10-13, 1998.
  16. Su Shih-Horng, Wu J., Landau C., Chao RYN., Timmons R. B., Meidell R. S., Nelson K. D., and Eberhart R. C.: Progress in bioresorbable polymer stent development Society For Biomaterials 25th Annual Meeting Providence, RI, April 26-May 2,1999
  17. Hu Z, Wang C, Nelson KD, Eberhart RC.: Controlled Release from a composite Silicone/Hydrogel Membrane. The American Society for Artificial Internal Organs, June 3-5, 1999
  18. Alikacem N, Yoshizawa T, Wilson C, Nelson KD.: In Vitro Measurement of Drug Release Concentrations Using MR Imaging. International Society for Magnetic Resonance in Medicine, Philadelphia, PA, May 1999
  19. Alikacem, N., Yoshizawa, T., Wilson, C., Nelson, KD. MRI Quantitation of Sustained VEGF Induced Blood-Retinal Barrier Breakdown: A Rabbit Study. International Society for Magnetic Resonance in Medicine, Eighth Scientific Meeting, Denver, USA, March 31-April7th, 2000.
  20. Alikacem, N., Yoshizawa, T., Wilson, C., Alappatt, J., Nelson, KD. Retinal Hyperpermeability Induced By Intravitreal VEGF Sustained Release: A Quantitative MRI Study In Rabbits. ARVO, 2000.
  21. SH Su, KD Nelson, RB Timmons, RS Meidell, and RC Eberhart. Expandable, bioresorbable endovascular stent with drug delivery capability. American Heart Association, 2001.
  22. Nagarathnamma Rangappa, Paula J. Waggoner, Kevin D. Nelson, Robert C. Eberhart and George M. Smith. Cellular responses to implantation of poly (L-lactide) microfilaments into the lesioned spinal cord. Biomedical Engineering Society Annual Meeting 2001.
  23. T.T.B. Ngo, P.J. Waggoner, A.A. Romero, K.D. Nelson, R.C. Eberhart, G.M. Smith. Bioresorbable filaments promote peripheral nerve regeneration across extended nerve lesions. Society of Neuroscience Annual meeting 2001.
  24. Nagarathnamma Rangappa, Kevin D. Nelson, George M. Smith. Cellular responses to implantation of poly (L-lactide) microfilaments into the lesioned spinal cord. Biomedical Engineering Society Meeting, October 4-7, 2001; Durham, NC
  25. Nagarathnamma Rangappa, Paula Waggoner, Kevin D. Nelson and George M. Smith. ‘Strategies to Induce Axonal Regeneration in the Injured Spinal Cord’ Kentucky Spinal Cord and Head Injury Research Trust (KSCHIRT) Symposium June 2002 held in Lexington, KY
  26. Kevin D. Nelson, Brent B. Crow, Nagrathnama Rangupa, Nadir Alikacem, George M. Smith. Innovative Fiber format for the Delivery of Proteins. International Controlled Release Society Meeting, July 21-25, 2002, Seoul, Korea.
  27. Delia Radulescu, Kevin D. Nelson. Chitosan-Based Scaffolds for Nerve Regeneration. International Congress on Biological and Medical Engineering, 4-7 Dec 2002; Singapore
  28. C.J. Chuong, K. Nelson, K. Behbehani and R.C. Eberhart. A Five-Year Degree Program Leading to a Bachelor of Science in Biology and a Master of Science in Biomedical Engineering. American Society for Engineering Education. March 20-21, 2003. Arlington, TX
  29. Khosrow Behbehani, Kevin D. Nelson and Robert C. Eberhart. A Biomedical Engineering Graduate Industrial Internship Program: Structure, Implementation, and Evaluation. American Society for Engineering Education. March 20-21, 2003. Arlington, TX
  30. XQ Tang, J Cai, K Nelson, XJ Peng, GM Smith. Functional regeneration of sensory afferents in severe dorsal root injury after bioresorbable guidance tube implantation and neurotrophin gene therapy. Neuroscience, 2003.
  31. J. Cai, K.D. Nelson, R. Eberhart, G.M. Smith. Synergistic Improvements of Cell/Axon Migration Using Resorbable Filaments and Human Heregulin-beta1. National BMES meeting October 2-4, 2003, Nashville, TN, USA.
  32. A. W. Beck, S. Holloway, Ganter J L M S, Nelson K, Eberhart R, Fleming JB, FACS. Ultrasound-guided placement of Bioresorbable Fibers into Pancreatic Adenocarcinoma Tumors achieves prolonged adenoviral gene transfer. American Chemical Society (ACS) Spring National Event, U. Virginia Newport News, VA February 26 to February 28, 2004
  33. Kevin D. Nelson, Joana Ganter, Jason Fleming. New Bi-Component Fibers Capable of Releasing Viruses with Retained Biological Activity. International Controlled Release Society, annual meeting. Honolulu, Hawaii, June 12-16, 2004
Patents

Kevin D. Nelson, Andres A. A. Romero-Sanchez, Nadir Alikacem, George M. Smith, Paula Waggoner, Delia Radulescu, Zhibing Hu: ‘Drug releasing biodegradable fiber implant’.
US 6,596,296

Kevin D. Nelson, Andres A. A. Romero-Sanchez, Nadir Alikacem, George M. Smith, Paula Waggoner, Delia Radulescu, Zhibing Hu: ‘Fabrication of drug-loaded, biodegradable polymer fibers’. US 6,858,222

Brent B. Crow, Kevin D. Nelson: ‘Drug releasing biodegradable fiber implant of various material and structural compositions used for the delivery of therapeutics’. US 7,033,603B2

Brent B. Crow, Kevin D. Nelson: ‘Drug releasing biodegradable fiber implant of various material and structural compositions used for the delivery of therapeutics’.
China 2004 8 0018348.8

Kevin D. Nelson, Andres A. A. Romero-Sanchez, Nadir Alikacem, George M. Smith, Paula Waggoner, Delia Radulescu, Zhibing Hu: Fabrication of drug loaded biodegradable polymer fibers’. US 7514095

Kevin D. Nelson, Brent B. Crow: ‘Self expanding Medical Device’ Application number 61/090,162 filed August 19, 2008.

Consulting Opportunities

May – July 1994 | St. Jude Medical, Inc.
Discover cause of blood clot formation on heart valve leaflet

June – August, 1996 | Johnson & Johnson Medical, Inc.
Full time consultant – Surgical Adhesion Prevention

Nov. 1996 -June 1997 | Mentor HS
Detectable physiochemical changes in drug content

Sept-December 1997 | Mark Brodeur, Attorney at Law
Expert Witness – Dental implant failure analysis

June – August, 1999 | Ball Semiconductor, Inc.
Full time consultant- Medical uses of spherical semiconductor