SCIENCE

TissueGen® develops polymer-based drug delivery systems for drugs ranging in size from small molecule compaunds to growth factors and enzymes to much larger antibodies. Our proprietary TGEM technology extends the range of pharmaceutical compounds we can formulate by protecting sensitive drugs from solvents used to manufacture polymer systems. The TissueGen team has decades of experience creating polymer-based drug-delivery systems from biodegradable fibers and microspheres using both customer supplied polymers as well as homopolymers, blends and co-polymers of common polymers including:

TECHNOLOGY

TissueGen® develops polymer-based drug delivery systems for drugs ranging in size

from small molecule compounds to growth factors and enzymes to much larger antibodies.

Our proprietary TGEM technology extends the range of pharmaceutical compounds we can
formulate by protecting sensitive drugs from solvents used to manufacture polymer systems.
The TissueGen team has decades of experience creating polymer-based drug-delivery
systems from biodegradable fibers and microspheres using both customer supplied
polymers as well as homopolymers, blends and co-polymers
of common polymers including:
 

Our proprietary TGEM technology protects sensitive biologics , such as antibodies, cytokines and growth factors throughout the polymer loading process. We’ve had great success creating extended release formulations of many biologic drugs, including:

TissueGen’s polymer-based drug-protected delivery systems are tuned to deliver hydrophobic and hydrophilic pharmaceutical agents. Our wet-extruded, drug-loaded fibers can be woven, braided, or knitted into drug-loaded textiles that are ideal for applications including soft-tissue healing, pain relief and protection against infection. Drug-loaded fibers and microspheres provide excellent flexibility in the design of slow release applications,  allowing us to optimize formulations while taking into consideration indication pharmacology, pharmacokinetics, and anatomical location of the drug depot.

PHARMACEUTICALS

TissueGen’s polymer-based drug-protected delivery systems are tuned to deliver

hydrophobic and hydrophilic pharmaceutical agents. Our wet-extruded, drug-loaded fibers 
can be woven, braided, or knitted into drug-loaded textiles that are ideal for applications 
including soft-tissue healing, pain relief and protection against infection. Drug-loaded fibers 
and microspheres provide excellent flexibility in the design of slow release applications,
 allowing us to optimize formulations while taking into consideration indication
pharmacology, pharmacokinetics, and anatomical location of the drug depot.

BIOLOGICS

Our proprietary TGEM technology protects sensitive biologics , such as

antibodies, cytokines and growth factors throughout the polymer loading process. 
We’ve had great success creating extended release formulations 
of many biologic drugs, including:

Poly(L-lactic acid) [PLLA]

Poly(L-lactic-co-glycolic acid) [PLGA]

Poly(D, L-lactic-co-glycolic acid) [PDLGA]

Poly(p-dioxanone) [PDO]

Poly (ε-caprolactone) [PCL]

Poly(ethylene glycol) [PEG]

 

Glial Derived Neutrophic Factor(GDNF)

Platelet Derived Growth Factor (PDGF-BB)

Transforming Growth Factor Beta (TGF-B1)

Trastuzumab Biosimilar

Bevacizumab

 
 

Unlike microsphere and nanoparticle drug delivery systems, ELUTE fiber provides both mechanical and pharmacological support from the same fiber. TissueGen’s biodegradable fiber format also offers many unique advantages over traditional drugs including:

KEY ADVANTAGES

Unlike microsphere and nanoparticle drug delivery systems, ELUTE fiber provides

both mechanical and pharmacological support from the same fiber. TissueGen’s

biodegradable fiber format also offers many unique advantages over traditional
drugs including: 

Longer therapeutic window

Targeted Positioning

Controlled and uniform distribution of drugs and biologics

Flexible formatting

TissueGen, Inc.
2110 Research Row, Suite 330
Dallas, Texas 75235
+ 1.214.351.1922
info@tissuegen.com

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